I am experiencing an annoying issue with my MX1000. Occassionally, when I come back to the computer after it's been in screen saver mode, the mouse does not respond. I have installed the new Setpoint 4.6 for Vista 64 and it still hasn't resolved the problem. I wind up having to unplug and then replug the USB in again in order for my computer to recognize the mouse again. Any help would be appreciated. Thanks!